Article
Suppressor of cytokine signaling 3 expression in anaplastic large cell lymphoma.
Leukemia - 1 Nov 2004
Cho-Vega J H, Rassidakis G Z, Amin H M, Tsioli P, Spurgers K, Remache Y K, Vega F, Goy A H, Gilles F, Medeiros L Jeffrey
Abstract excerpt
Using a cDNA microarray, we found that suppressor of cytokine signaling 3 (SOCS3) is highly expressed in anaplastic lymphoma kinase (ALK)+ anaplastic large cell lymphoma (ALCL) cell lines. As SOCS3 is induced by activated signal transducer and activator of transcription 3 (STAT3), and ALK activates STAT3, we hypothesized that SOCS3 may play a role in ALK+ ALCL pathogenesis via the Janus kinase 3 (JAK3)-STAT3...
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