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Constitutive expression of SOCS3 confers resistance to IFN-α in chronic myelogenous leukemia cells

26 Sept 2002

Abstract excerpt

Because suppressor of cytokine signaling (SOCS) proteins are negative regulators of cytokine-induced signaling, it has been hypothesized that aberrant SOCS expression confers resistance against cytokine therapy. This study reports on the constitutive expression of SOCS3 in most chronic myelogenous leukemia (CML) cell lines, which are resistant to treatment with interferon alpha (IFN-alpha). In contrast, the...

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PMID: 12351404
DOI: 10.1182/blood-2002-01-0073

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