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Article

Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation.

The Journal of experimental medicine - 6 May 2013

Cohn Lillian, Chatterjee Bithi, Esselborn Filipp, Smed-Sörensen Anna, Nakamura Norihiro, Chalouni Cécile, Lee Byoung-Chul, Vandlen Richard, Keler Tibor, Lauer Peter, Brockstedt Dirk, Mellman Ira, Delamarre Lélia

Abstract excerpt

Human BDCA3(+) dendritic cells (DCs), the proposed equivalent to mouse CD8α(+) DCs, are widely thought to cross present antigens on MHC class I (MHCI) molecules more efficiently than other DC populations. If true, it is unclear whether this reflects specialization for cross presentation or a generally enhanced ability to present antigens on MHCI. We compared presentation by BDCA3(+) DCs with BDCA1(+) DCs using a...

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Identifiers

PMID: 23569326
DOI: 10.1084/jem.20121251
PMCID: PMC3646496

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