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Article

Serum amyloid A-activating factor-1 (SAF-1) transgenic mice are prone to develop a severe form of inflammation-induced arthritis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2004

Ray Alpana, Kumar Deepak, Shakya Arvind, Brown Charles R, Cook James L, Ray Bimal K

Abstract excerpt

The transcription factor serum amyloid A-activating factor-1 (SAF-1) has been identified as a regulator of a number of cellular genes. To assess the pleiotropic role of SAF-1 in vivo, we generated SAF-1 transgenic mice, in which CMV immediate-early promoter was used to direct expression of the SAF-1 transgene in multiple organs. Our study shows that overexpression of SAF-1 predisposes animals to arthritis....

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Identifiers

PMID: 15383604
DOI: 10.4049/jimmunol.173.7.4684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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