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Article

Inflammation-responsive transcription factor SAF-1 activity is linked to the development of amyloid A amyloidosis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2006

Ray Alpana, Shakya Arvind, Kumar Deepak, Benson Merrill D, Ray Bimal K

Abstract excerpt

Abundantly expressed serum amyloid A (SAA) protein under chronic inflammatory conditions gives rise to insoluble aggregates of SAA derivatives in multiple organs resulting in reactive amyloid A (AA) amyloidosis, a consequence of rheumatoid arthritis, Crohn's disease, ankylosing spondylitis, familial Mediterranean fever, and Castleman's disease. An inflammation-responsive transcription factor, SAF (for SAA...

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Source

Identifiers

PMID: 16888022
DOI: 10.4049/jimmunol.177.4.2601

Genes

SAA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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