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Article

Haploinsufficiency and reduced expression of genes localized to the 8p chromosomal region in human prostate tumors.

Genes, chromosomes & cancer - 1 Jul 2003

Chaib Hassan, MacDonald James W, Vessella Robert L, Washburn Joseph G, Quinn Janna E, Odman Austin, Rubin Mark A, Macoska Jill A

Abstract excerpt

Cytogenetic and molecular studies have suggested that deletion or rearrangement of sequences that map to the short arm of chromosome 8 may be permissive for tumorigenesis in several organ systems, and in human prostate tumors in particular. In this study, we hypothesized that genes deleted for one copy and localized to the 8p chromosomal region may be transcriptionally down-regulated or ablated in affected human...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12759929
DOI: 10.1002/gcc.10226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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