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Article

Evaluation of immunogenicity and protective properties of inactivated poliovirus vaccines: a new surrogate method for predicting vaccine efficacy.

The Journal of infectious diseases - 15 Oct 2004

Dragunsky Eugenia M, Ivanov Alexander P, Wells Virgen R, Ivshina Anna V, Rezapkin Gennady V, Abe Shinobu, Potapova Svetlana G, Enterline Joan C, Hashizume Sou, Chumakov Konstantin M

Abstract excerpt

An assay for the evaluation of protective properties of inactivated poliovirus vaccines (IPVs) in transgenic (Tg) mice susceptible to poliovirus has been developed and optimized for type 2 IPV. This method was used to compare the immunogenicity and protective properties of experimental IPV produced from the attenuated Sabin strain (sIPV) with those of conventional IPV (cIPV) produced from the wild-type (wt)...

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Identifiers

PMID: 15378432
DOI: 10.1086/424524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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