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Functional Characterization of the Candidate Tumor Suppressor Gene <b> <i>NPRL2</i> </b>/<b> <i>G21</i> </b> Located in 3p21.3C

15 Sept 2004

Abstract excerpt

Initial analysis identified the NPRL2/G21 gene located in 3p21.3C, the lung cancer region, as a strong candidate tumor suppressor gene. Here we provide additional evidence of the tumor suppressor function of NPRL2/G21. The gene has highly conserved homologs/orthologs ranging from yeast to humans. The yeast ortholog, NPR2, shows three highly conserved regions with 32 to 36% identity over the whole length. By...

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PMID: 15374952
DOI: 10.1158/0008-5472.can-03-3869

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