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Article

Growth inhibitory effect of the human NIT2 gene and its allelic imbalance in cancers

4 May 2007

Abstract excerpt

The mammalian nitrilase (Nit) protein is a member of the nitrilase superfamily whose function remains to be characterized. We now show that the nitrilase family member 2 gene (NIT2) is ubiquitously expressed in multiple tissues and encodes protein mainly distributed in the cytosol. Ectopic expression of Nit2 in HeLa cells was found to inhibit cell growth through G(2) arrest rather than by apoptosis. Consistent...

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PMID: 17488281
DOI: 10.1111/j.1742-4658.2007.05828.x

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