Article
An explanation for the defect in secretion of IgM Mott cells and their predominant occurrence in the Ly-1 B cell compartment.
European journal of immunology - 1 Feb 1992
Tarlinton D, Förster I, Rajewsky K
Abstract excerpt
Mott cells are a variant form of plasma cell in which the immunoglobulin (Ig), rather than being secreted, accumulates in rough endoplasmic reticulum-derived vesicles called Russell bodies. We have examined the molecular cause of this defect and the in vivo origin of IgM Mott cells. Our examinati...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Ly
- B-Lymphocyte Subsets
- Base Sequence
- Cell Compartmentation
- Cytoplasm
- DNA Mutational Analysis
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Genes, Immunoglobulin
- Hybridomas
- Immunoglobulin M
- Immunoglobulin Variable Region
- Immunoglobulin mu-Chains
- In Vitro Techniques
- Mice
- Molecular Sequence Data