Mutant nicastrin protein can induce the cytochrome c release and the Bax expression.

Abstract excerpt

This study investigated whether nicastrin can induce apoptotic cell death in SK-N-MC cells. MTT assays revealed the transfected cells expressing mutant nicastrin, compared with those expressing wild nicastrin or the control vector, showing significantly increased cell death. The mutant nicastrin transfectants were also observed to induce cytosolic cytochrome c release from the mitochondria, and Bax protein...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Tetrazolium Salts
• Share to Amyloid Precursor Protein Secretases