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Article

Restoration of TRAIL‐Induced Apoptosis in a Caspase‐8‐Deficient Neuroblastoma Cell Line by Stable Re‐expression of Caspase‐8

1 Dec 2003

Abstract excerpt

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in most tumor cells, a process sometimes potentiated by chemotherapeutic drugs or cycloheximide (CHX). Childhood neuroblastoma (NB) is a clinically and biologically heterogeneous neoplasm whose behavior can be explained by differential regulation of apoptosis. The non-invasive S-type NB cell lines are sensitive to TRAIL,...

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PMID: 15033719
DOI: 10.1196/annals.1299.033

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