Article
Thioredoxin interacting protein in Dutch families with familial combined hyperlipidemia.
American journal of medical genetics. Part A - 15 Sept 2004
van der Vleuten Gerly M, Hijmans Anneke, Kluijtmans Leo A J, Blom Henk J, Stalenhoef Anton F H, de Graaf Jacqueline
Abstract excerpt
Familial combined hyperlipidemia (FCH), characterized by multiple lipoprotein phenotypes, is the most common hereditary lipid disorder in humans. A mutant mouse strain, HcB-19, with similar biochemical features as FCH patients, has recently been identified. The mutation causing the FCH phenotype in these mice is located in the thioredoxin interacting protein (TXNIP) gene. The TXNIP gene in mice is located on...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.