Article
TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study.
Atherosclerosis - 1 Jun 2004
Coon Hilary, Singh Nanda, Dunn Diane, Eckfeldt John H, Province Michael A, Hopkins Paul N, Weiss Robert, Hunt Steven C, Leppert Mark F
Abstract excerpt
Familial combined hyperlipidemia (FCHL) is the most common familial dyslipidemia, and is implicated in up to 20% of cases of premature coronary heart disease. Positive linkage to chromosome 1q was found in FCHL families participating in the NHLBI Family Heart Study (FHS), replicating linkage found in other studies. The HcB-19 mouse, which shares phenotypes with FCHL, was shown in other studies to have a nonsense...
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