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Article

Genetic variability in the ACE gene region surrounding the Alu I/D polymorphism is maintained by balancing selection in human populations.

Pharmacogenetics and genomics - 1 Feb 2010

Cagliani Rachele, Fumagalli Matteo, Riva Stefania, Pozzoli Uberto, Comi Giacomo P, Bresolin Nereo, Sironi Manuela

Abstract excerpt

OBJECTIVE: Angiotensin-converting enzyme plays a critical role in the maintenance of cardiovascular homeostasis. Extensive research has aimed at identifying ACE genetic variants responsible for variation in enzyme plasma concentrations and associated with human diseases. These efforts have been hampered by the extensive linkage disequilibrium across the gene and the identity or location of the functional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20038859
DOI: 10.1097/FPC.0b013e3283333532

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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