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Article

In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase.

The Journal of biological chemistry - 4 Mar 2005

Kitazume Shinobu, Nakagawa Kazuhiro, Oka Ritsuko, Tachida Yuriko, Ogawa Kazuko, Luo Yi, Citron Martin, Shitara Hiroshi, Taya Choji, Yonekawa Hiromichi, Paulson James C, Miyoshi Eiji, Taniguchi Naoyuki, Hashimoto Yasuhiro

Abstract excerpt

beta-Site amyloid precursor protein-cleaving enzyme 1 (BACE1) is a membrane-bound aspartic protease that cleaves amyloid precursor protein to produce a neurotoxic peptide, Abeta, and is implicated in triggering the pathogenesis of Alzheimer disease. We previously reported that BACE1 cleaved rat b...

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Source

Identifiers

PMID: 15364953
DOI: 10.1074/jbc.M409417200

Genes

BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15364953-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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