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Skipping the co-expression problem: the new 2A "CHYSEL" technology

13 Sept 2004

Abstract excerpt

The rapid progress in the field of genomics is increasing our knowledge of multi-gene diseases. However, any realistic hope of gene therapy treatment for those diseases needs first to address the problem of co-ordinately co-expressing several transgenes. Currently, the use of internal ribosomal entry sites (IRESs) is the strategy chosen by many researchers to ensure co-expression. The large sizes of the IRESs...

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PMID: 15363111
DOI: 10.1186/1479-0556-2-13

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