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Article

Protein Coexpression Using FMDV 2A: Effect of “Linker” Residues

1 Jan 2013

Abstract excerpt

Many biomedical applications absolutely require, or are substantially enhanced by, coexpression of multiple proteins from a single vector. Foot-and-mouth disease virus 2A (F2A) and "2A-like" sequences (e.g., Thosea asigna virus 2A; T2A) are used widely for this purpose since multiple proteins can be coexpressed by linking open reading frames (ORFs) to form a single cistron. The activity of F2A "cleavage" may,...

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PMID: 23878801
DOI: 10.1155/2013/291730

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