Article
Functional sites of human PCNA which interact with p21 (Cip1/Waf1), DNA polymerase delta and replication factor C.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 1998
Oku T, Ikeda S, Sasaki H, Fukuda K, Morioka H, Ohtsuka E, Yoshikawa H, Tsurimoto T
Abstract excerpt
BACKGROUND: PCNA, an eukaryotic DNA sliding clamp interacts with replication factors and the cell cycle protein, p21(Cip1/Waf1) and functions as a molecular switch for DNA elongation. To understand how DNA replication is regulated through PCNA, elucidation of the precise mechanisms of these prote...
Topics
- Adenosine Triphosphatases
- Binding Sites
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA
- DNA Polymerase III
- DNA-Binding Proteins
- Homeodomain Proteins
- Humans
- Minor Histocompatibility Antigens
- Mutation