Article
Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis.
The Journal of allergy and clinical immunology - 1 Sept 2004
Heinzmann Andrea, Ahlert Iris, Kurz Thorsten, Berner Reinhard, Deichmann Klaus A
Abstract excerpt
BACKGROUND: IL-8 is a strong inductor of inflammation. Accordingly, it plays a pivotal role in acute inflammatory responses during respiratory syncytial virus (RSV) infections and in chronic inflammatory diseases such as bronchial asthma and juvenile idiopathic arthritis. Recently, 2 studies have found association of the polymorphism -251A of IL8 with RSV bronchiolitis. Furthermore, epidemiologic studies have...
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