Article
Low frequency of BRAFT1796A mutations in childhood thyroid carcinomas.
The Journal of clinical endocrinology and metabolism - 1 Sept 2004
Kumagai Atsushi, Namba Hiroyuki, Saenko Vladimir A, Ashizawa Kiyoto, Ohtsuru Akira, Ito Masahiro, Ishikawa Naofumi, Sugino Kiminori, Ito Koichi, Jeremiah Stephen, Thomas Geraldine A, Bogdanova Tatyana I, Tronko Mykola D, Nagayasu Takeshi, Shibata Yoshisada, Yamashita Shunichi
Abstract excerpt
A high prevalence of the activating BRAF mutation, BRAF(T1796A), is observed in adult papillary thyroid carcinomas (PTCs). The prognosis of childhood PTCs is generally fairly good despite the fact that distant metastases are often documented in these cases. To investigate the differences between the characteristics of childhood and adult PTCs, we analyzed both BRAF(T1796A) and RAS mutations in 31 Japanese and 48...
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