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Article

BRAF mutations are not a major event in post-Chernobyl childhood thyroid carcinomas.

The Journal of clinical endocrinology and metabolism - 1 Sept 2004

Lima Jorge, Trovisco Vítor, Soares Paula, Máximo Valdemar, Magalhães João, Salvatore Giuliana, Santoro Massimo, Bogdanova Tatyana, Tronko Mykola, Abrosimov Alexander, Jeremiah Steve, Thomas Gerry, Williams Dillwyn, Sobrinho-Simões Manuel

Abstract excerpt

The BRAF gene has been shown to be a major target for mutations in papillary thyroid carcinoma (PTC) (36-69%), which forms almost all of the over 2000 cases of thyroid carcinoma that have occurred in Chernobyl. BRAF is activated by point mutation, and were it to occur at a high frequency in Chernobyl-related tumors, it would challenge the dominant role of double-strand breaks in radiation-induced PTC. In a...

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Identifiers

PMID: 15356020
DOI: 10.1210/jc.2003-032224

Genes

BRAF
RET

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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