Article
Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer.
British journal of clinical pharmacology - 1 Apr 2005
Zhou Qingyu, Sparreboom Alex, Tan Eng-Huat, Cheung Yin-Bun, Lee Ann, Poon Donald, Lee Edmund J D, Chowbay Balram
Abstract excerpt
AIMS: The aim of this exploratory study was to investigate associations between irinotecan pharmacokinetic parameters and allelic variants in genes encoding for drug transporters and drug metabolizing enzymes that are involved in irinotecan disposition in Asian patients with cancer. METHODS: Irin...
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