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Article

Removal of clustered positive charge from dihydropyridine receptor II-III loop peptide augments activation of ryanodine receptors.

Biochemical and biophysical research communications - 13 Feb 2004

Bannister Mark L, Williams Alan J, Sitsapesan Rebecca

Abstract excerpt

Peptides based on the skeletal muscle DHPR II-III loop have been shown to regulate ryanodine receptor channel activity. The N-terminal region of this cytoplasmic loop is predicted to adopt an alpha-helical conformation. We have selected a peptide sequence of 26 residues (Ala(667)-Asp(692)) as the minimum sequence to emulate the helical propensity of the corresponding protein sequence. The interaction of this...

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Source

Identifiers

PMID: 14741687
DOI: 10.1016/j.bbrc.2003.12.128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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