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Article

FLT3 mutations in myeloid sarcoma.

British journal of haematology - 1 Sept 2004

Ansari-Lari M Ali, Yang Ching-Fen, Tinawi-Aljundi Rima, Cooper Lisa, Long Patricia, Allan Robert H, Borowitz Michael J, Berg Karin D, Murphy Kathleen M

Abstract excerpt

Myeloid sarcoma is an extramedullary tumour that typically occurs in the setting of acute myeloid leukaemia (AML), or myeloproliferative disorders. In AML, two types of mutations in Fms-like tyrosine kinase 3 (FLT3) have been described; internal tandem duplications (ITD) and point mutations at aspartic acid residue 835 (D835). We analysed 24 myeloid sarcoma specimens from 20 patients for FLT3 ITD and D835...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15352981
DOI: 10.1111/j.1365-2141.2004.05124.x

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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FLT3 mutations in myeloid sarcoma.PMID 15352981Read ↗

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Clinical and molecular features of FLT3 juxtamembrane domain missense mutations in acute myeloid leukaemia.Semantic proximity Read ↗

Non-internal tandem duplication (ITD), non-tyrosine kinase domain (TKD) FLT3 mutations in myeloid malignancies: A brief report of 10 patients.Semantic proximity Read ↗

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Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome.Semantic proximity Read ↗

Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation.Semantic proximity Read ↗

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