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Article

Differential SERM effects on corepressor binding dictate ERalpha activity in vivo.

The Journal of biological chemistry - 28 Feb 2003

Webb Paul, Nguyen Phuong, Kushner Peter J

Abstract excerpt

Selective estrogen receptor modulators (SERMs) show differential effects upon ERalpha activation function 1 (AF-1). Tamoxifen allows strong ERalpha AF-1 activity, whereas raloxifene allows less and ICI 182,780 (ICI) allows none. Here, we show that blockade of corepressor histone de-acetylase (HDAC) activity reverses the differential inhibitory effect of SERMs upon AF-1 activity in MCF-7 cells. This suggests that...

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Source

Identifiers

PMID: 12482846
DOI: 10.1074/jbc.M208501200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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