Article
Phylogenetic discovery bias in Bacillus anthracis using single-nucleotide polymorphisms from whole-genome sequencing.
Proceedings of the National Academy of Sciences of the United States of America - 14 Sept 2004
Pearson Talima, Busch Joseph D, Ravel Jacques, Read Timothy D, Rhoton Shane D, U'Ren Jana M, Simonson Tatum S, Kachur Sergey M, Leadem Rebecca R, Cardon Michelle L, Van Ert Matthew N, Huynh Lynn Y, Fraser Claire M, Keim Paul
Abstract excerpt
Phylogenetic reconstruction using molecular data is often subject to homoplasy, leading to inaccurate conclusions about phylogenetic relationships among operational taxonomic units. Compared with other molecular markers, single-nucleotide polymorphisms (SNPs) exhibit extremely low mutation rates, making them rare in recently emerged pathogens, but they are less prone to homoplasy and thus extremely valuable for...
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