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Article

Effects of the ApoE epsilon4 allele on olfactory function in Down syndrome.

Journal of Alzheimer's disease : JAD - 1 Aug 2004

Sliger Melissa, Lander Timothy, Murphy Claire

Abstract excerpt

The present study investigated the effects of the apolipoprotein E (ApoE) epsilon4 allele, a risk factor for Alzheimer's disease (AD), on olfactory function in Down syndrome (DS). Brain areas critical to olfactory processing, particularly the entorhinal cortex, show the earliest neuropathological changes in AD. Functionally, odor identification has been shown to be impaired in AD and in persons with the epsilon4...

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Identifiers

PMID: 15345810
DOI: 10.3233/jad-2004-6407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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