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Article

Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface.

The Journal of biological chemistry - 3 Dec 2004

Kleinau Gunnar, Jäschke Holger, Neumann Susanne, Lättig Jens, Paschke Ralf, Krause Gerd

Abstract excerpt

Glycoprotein hormone receptors (GPHRs) differ from the other seven transmembrane receptors mainly through a complex activation mechanism that requires the binding of a large hormone toward a large N-terminal ectodomain. The intramolecular mechanism of the signal transduction to the serpentine dom...

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Source

Identifiers

PMID: 15345720
DOI: 10.1074/jbc.M404748200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15345720-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface.PMID 15345720Read ↗

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