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Article

Analyses of glutathione reductase hypomorphic mice indicate a genetic knockout.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Dec 2004

Rogers Lynette K, Tamura Toshiya, Rogers Bryan J, Welty Stephen E, Hansen Thomas N, Smith Charles V

Abstract excerpt

A strain of mice (Gr1a1Neu) that exhibited tissue glutathione reductase (GR) activities that were substantially lower (less than 10% in liver) than the corresponding activities in control mice has been reported. The present report describes characterization of the mutation(s) in the GR gene of these mice. RT-PCR of mRNA from the Neu mice indicated a substantial deletion in the normal GR coding sequence. Southern...

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Identifiers

PMID: 15342956
DOI: 10.1093/toxsci/kfh268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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