Article
The ADPRT V762A genetic variant contributes to prostate cancer susceptibility and deficient enzyme function.
Cancer research - 1 Sept 2004
Lockett Kristin L, Hall M Craig, Xu Jianfeng, Zheng S Lilly, Berwick Marianne, Chuang Shu-Chun, Clark Peter E, Cramer Scott D, Lohman Kurt, Hu Jennifer J
Abstract excerpt
The ADP-ribosyltransferase (ADPRT) gene encodes a zinc-finger DNA-binding protein, poly(ADP-ribose) polymerase-1 (PARP-1), that modifies various nuclear proteins by poly(ADP-ribosyl)ation and functions as a key enzyme in the base excision repair pathway. We have conducted two studies to test whether an amino acid substitution variant, ADPRT V762A (T2444C), is associated with prostate cancer (CaP) risk and...
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