Article
TEL2, an ETS factor expressed in human leukemia, regulates monocytic differentiation of U937 Cells and blocks the inhibitory effect of TEL1 on ras-induced cellular transformation.
Cancer research - 1 Sept 2004
Kawagoe Hiroyuki, Potter Mark, Ellis John, Grosveld Gerard C
Abstract excerpt
TEL2 is a member of the ETS family of transcription factors, which is highly similar to TEL1/ETV6. It binds to DNA via the ETS domain and interacts with itself or TEL1 via the pointed domain. The expression of TEL2 in normal and leukemic hematopoietic cells suggests a role in hematopoietic development. In this article, we describe the role of TEL2 in hematopoietic differentiation and cellular transformation....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.