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Article

Complete RNAi rescue of neuronal degeneration in a constitutively active Drosophila TRP channel mutant.

Biochimica et biophysica acta - 6 Sept 2004

Geng Chaoxian, Pellegrino Ann, Bowman John, Zhu Liqin, Pak William L

Abstract excerpt

RNA interference has been widely used to reduce the quantity of the proteins encoded by the targeted genes. A constitutively active, dominant allele of trp, TrpP365, causes massive degeneration of photoreceptors through a persistent and excessive Ca2+ influx. Here we show that a substantial reduction of the TRP channel protein by RNAi in TrpP365 heterozygotes completely rescues the neuronal degeneration and...

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Source

Identifiers

PMID: 15342118
DOI: 10.1016/j.bbagen.2004.06.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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