Article
In vivo identification and manipulation of the Ca2+ selectivity filter in the Drosophila transient receptor potential channel.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Jan 2007
Liu Che H, Wang Tao, Postma Marten, Obukhov Alexander G, Montell Craig, Hardie Roger C
Abstract excerpt
Null mutations in the transient receptor potential (trp) gene eliminate the major, Ca2+-selective component of the light-sensitive conductance in Drosophila photoreceptors. Although it is the prototypical member of the TRP ion channel superfamily, conclusive evidence that TRP is a pore-forming channel subunit in vivo is lacking. We show here that mutating a specific acidic residue (Asp621) in the putative pore...
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