Article
Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility.
Proceedings of the National Academy of Sciences of the United States of America - 14 Sept 2004
Nolan Michael A, Babcock Donner F, Wennemuth Gunther, Brown William, Burton Kimberly A, McKnight G Stanley
Abstract excerpt
An unusual cAMP signaling system mediates many of the events that prepare spermatozoa to meet the egg. Its components include the atypical, bicarbonate-stimulated, sperm adenylyl cyclase and a cAMP-dependent protein kinase (PKA) with the unique catalytic subunit termed Calpha(2) or C(s). We generated mice that lack Calpha(2) to determine its importance in the events downstream of cAMP production. Male Calpha(2)...
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