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Article

Protein phosphatase PP1?2 in sperm morphogenesis and epididymal initiation of sperm motility

1 Jul 2007

Abstract excerpt

The serine/threonine phosphatase (PP1) isoform PP1 gamma 2, predominantly expressed in the testis, is a key enzyme in spermatozoa. High PP1 gamma 2 catalytic activity holds motility in check in immature spermatozoa. Inhibition of PP1 gamma 2 causes motility initiation in immature spermatozoa and motility stimulation and changes in flagellar beat parameters in mature spermatozoa. The PP1 gamma 2 isoform is present...

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PMID: 17589781
DOI: 10.1111/j.1745-7262.2007.00307.x

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