Article
Identification of two novel splicing variants of human type II iodothyronine deiodinase mRNA.
Molecular and cellular endocrinology - 14 Feb 2001
Ohba K, Yoshioka T, Muraki T
Abstract excerpt
Human type II iodothyronine deiodinase (hDII) belongs to a family of selenoproteins. It catalyzes 5'-deiodination of thyroxine to generate an active thyroid hormone, 3,3',5-triiodothyronine. Two novel splice variants of hDII gene transcript; namely hDII-b and hDII-c, were identified. Three distinct DNA fragments (hDII-a-c) were amplified by a reverse transcription-polymerase chain reaction (RT-PCR) with hDII...
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