Article
Sequence-based linkage analysis.
American journal of human genetics - 1 Oct 2004
Furman Itay, Rieder Mark J, Da Ponte Suzanne, Carrington Dana P, Nickerson Deborah A, Kruglyak Leonid, Markianos Kyriacos
Abstract excerpt
The rapid decrease in the cost of DNA sequencing will enable its use for novel applications. Here, we investigate the use of DNA sequencing for simultaneous discovery and genotyping of polymorphisms in family linkage studies. In the proposed approach, short contiguous segments of genomic DNA, reg...
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