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Article

Epidermal growth factor receptor mutations and susceptibility to targeted therapy in lung cancer.

Respirology (Carlton, Vic.) - 1 Nov 2006

Ahmed Syed M, Salgia Ravi

Abstract excerpt

According to 2002 estimates, 1.35 million people were diagnosed with and 1.18 million died of lung cancer worldwide. Recently, a new class of medications targeting signal transduction pathways has come into focus in the treatment of various malignancies. In lung cancer, the molecules gefitinib and erlotinib which target the intracellular kinase domain of the epidermal growth factor receptor (EGFR), cause...

Topics

Antineoplastic Agents
DNA, Neoplasm
Drug Resistance, Neoplasm
Enzyme Inhibitors
ErbB Receptors
Erlotinib Hydrochloride
Gefitinib
Gene Deletion
Gene Expression Regulation, Neoplastic
Humans
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Protein-Tyrosine Kinases

Quinazolines

Source

Identifiers

PMID: 17052295
DOI: 10.1111/j.1440-1843.2006.00887.x

Genes

EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17052295-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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