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Article

Discovery of drugs that directly target the intrinsically disordered region of the androgen receptor

26 Feb 2020

Abstract excerpt

Introduction: Intrinsically disordered proteins (IDPs) and regions (IDRs) lack stable three-dimensional structure making drug discovery challenging. A validated therapeutic target for diseases such as prostate cancer is the androgen receptor (AR) which has a disordered amino-terminal domain (NTD) that contains all of its transcriptional activity. Drug discovery against the AR-NTD is of intense interest as a...

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PMID: 32100577
DOI: 10.1080/17460441.2020.1732920

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