[Genotype-disease association and possibility to reveal environmentally modifiable disease causes: the use of mendelian randomization principle].

Abstract excerpt

Though the methodology and designs of epidemiological studies and analyses of medical databases have improved, associations between modifiable exposures and the disease in observational epidemiological studies remain partly biased. Mendelian randomization principle, which is the random distribution of parental genes to offspring in meiosis during gametogeneis and at conception, represents a chance for methodology...

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