Article
TCR gamma delta bearing T lymphocytes infiltrating human primary cutaneous melanomas.
The Journal of investigative dermatology - 1 Mar 1992
Bachelez H, Flageul B, Degos L, Boumsell L, Bensussan A
Abstract excerpt
In situ immunophenotypic studies show that tumor infiltrating T lymphocytes from six of 11 fresh cutaneous primary melanomas tested contain T-cell receptor gamma delta expressing cells whereas those from 8 metastatic melanomas did not. In three cases these cells represent an unexpectedly high proportion of the lymphocytic infiltrate, ranging from 15 to 25%. This elevated percentage is maintained when tumor...
Topics
- Humans
- Lymphocytes, Tumor-Infiltrating
- Melanoma
- Neoplasm Metastasis
- Phenotype
- Receptors, Antigen, T-Cell, alpha-beta
- Receptors, Antigen, T-Cell, gamma-delta
- Skin Neoplasms
- T-Lymphocytes
- Tumor Cells, Cultured