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Article

Interaction between altered insulin and lipid metabolism in CEACAM1-inactive transgenic mice.

The Journal of biological chemistry - 22 Oct 2004

Dai Tong, Abou-Rjaily George A, Al-Share' Qusai Y, Yang Yan, Fernström Mats A, Deangelis Anthony M, Lee Abraham D, Sweetman Lawrence, Amato Antonino, Pasquali Marzia, Lopaschuk Gary D, Erickson Sandra K, Najjar Sonia M

Abstract excerpt

Inactivation of CEACAM1 in L-SACC1 mice by a dominant-negative transgene in liver impairs insulin clearance and increases serum free fatty acid (FFA) levels, resulting in insulin resistance. The contribution of elevated FFAs in the pathogenesis of insulin resistance is herein investigated. Treatment of L-SACC1 female mice with carnitine restored plasma FFA content. Concomitantly, it normalized insulin levels...

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Share to 3-Hydroxybutyric Acid
Share to Carcinoembryonic Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carnitine

Share to Coenzyme A

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Share to Fatty Acids, Nonesterified

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Source

Identifiers

PMID: 15316023
DOI: 10.1074/jbc.M404764200

Genes

CEACAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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