Article
The transcription factor CCAAT-binding factor CBF/NF-Y and two repressors regulate the core promoter of the human pro-alpha3(V) collagen gene (COL5A3).
The Journal of biological chemistry - 5 Nov 2004
Nagato Hitoshi, Matsuo Noritaka, Sumiyoshi Hideaki, Sakata-Takatani Keiko, Nasu Masaru, Yoshioka Hidekatsu
Abstract excerpt
To elucidate the mechanisms underlining alpha3(V) collagen chain expression, we performed an initial analysis of the structure and function of the core promoter of the human COL5A3 gene. The core promoter, which lacks a typical TATA motif and has a high GC content, was defined within the -129 bp immediately upstream from the major transcription start site by transient transfection experiments. In this region, we...
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