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Article

Complete knockout of estrogen receptor alpha is not directly protective in murine lupus.

Clinical immunology (Orlando, Fla.) - 1 Oct 2017

Scott Jennifer L, Wirth Jena R, Eudaly Jackie, Ruiz Phil, Cunningham Melissa A

Abstract excerpt

Systemic lupus erythematosus (SLE) is a chronic and potentially severe autoimmune disease that disproportionately affects women. Despite a known role for hormonal factors impacting autoimmunity and disease pathogenesis, the specific mechanisms of action remain poorly understood. Our laboratory previously backcrossed "estrogen receptor alpha knockout (ERαKO)" mice onto the NZM2410 lupus prone background to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28822833
DOI: 10.1016/j.clim.2017.08.010
PMCID: PMC6261466

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