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Paralogous Cyp51s mediate the differential sensitivity of <i>Fusarium oxysporum</i> to sterol demethylation inhibitors

22 Jun 2018

Abstract excerpt

BACKGROUND: As a soilborne fungus, Fusarium oxysporum can cause vascular wilt in numerous economically important crops. Application of antifungal drugs is the primary method for the control of F. oxysporum. Cyp51, a key enzyme of sterol biosynthesis is the main target of sterol demethylation inhibitors. RESULTS: The F. oxysporum genome contains three paralogous CYP51 genes (named FoCYP51A, FoCYP51B and FoCYP51C)...

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PMID: 29931739
DOI: 10.1002/ps.5127

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