Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hormone-Induced Chromosomal Instability in p53-Null Mammary Epithelium

15 Aug 2004

Abstract excerpt

The absence of p53 function increases risk for spontaneous tumorigenesis in the mammary gland. Hormonal stimulation enhances tumor risk in p53-null mammary epithelial cells as well as the incidence of aneuploidy. Aneuploidy appears in normal p53-null mammary epithelial cells within 5 weeks of hormone stimulation. Experiments reported herein assessed a possible mechanism of hormone-induced aneuploidy. Hormones...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Hedgehog Signaling Pathway Studies
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15313898
DOI: 10.1158/0008-5472.can-03-0629

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hormone-Induced Chromosomal Instability in p53-Null Mammary EpitheliumPMID 15313898Read ↗

Progesterone facilitates chromosome instability (aneuploidy) in p53 null normal mammary epithelial cells.Semantic proximity Read ↗

Hormonal control of p53 and chemoprevention.Semantic proximity Read ↗

Activation of mitogen- and stress-activated kinase 1 is required for proliferation of breast cancer cells in response to estrogens or progestins.Semantic proximity Read ↗

Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice.Semantic proximity Read ↗

Spontaneous and induced aneuploidy, considerations which may influence chromosome malsegregation.Semantic proximity Read ↗

Estrogen mediation of breast tumor formation involves estrogen receptor-dependent, as well as independent, genotoxic effects.Semantic proximity Read ↗

Hormone-induced protection of mammary tumorigenesis in genetically engineered mouse modelsSemantic proximity Read ↗

Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation.Semantic proximity Read ↗

Carcinogenicity of estrogens in human breast epithelial cells.Semantic proximity Read ↗

Characterization of DNA damage-dependent cell cycle checkpoints in a menin-deficient model.Semantic proximity Read ↗

Long-term hormonal promotion overcomes genetic resistance to mammary cancer.Semantic proximity Read ↗

Mps1 as a link between centrosomes and genomic instability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.