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Article

Loss of Apolipoprotein E Receptor LR11 in Alzheimer Disease

1 Aug 2004

Abstract excerpt

BACKGROUND: Genetic, epidemiologic, and biochemical evidence suggests that apolipoprotein E, low-density lipoprotein receptors, and lipid metabolism play important roles in sporadic Alzheimer disease (AD). OBJECTIVE: To identify novel candidate genes associated with sporadic AD. DESIGN: We performed an unbiased microarray screen for genes differentially expressed in lymphoblasts of patients with sporadic AD and...

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PMID: 15313836
DOI: 10.1001/archneur.61.8.1200

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Related research

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Research trail→

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Loss of Apolipoprotein E Receptor LR11 in Alzheimer DiseasePMID 15313836Read ↗

LR11/SorLA Expression Is Reduced in Sporadic Alzheimer Disease but not in Familial Alzheimer DiseaseSemantic proximity Read ↗

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Predicted gene sequence C10orf112 is transcribed, exhibits tissue-specific expression, and may correspond to AD7.Semantic proximity Read ↗

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Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease.Semantic proximity Read ↗

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