Article
Increased levels of soluble LR11 in cerebrospinal fluid of patients with Alzheimer disease.
Dementia and geriatric cognitive disorders - 1 Jan 2010
Ikeuchi Takeshi, Hirayama Satoshi, Miida Takashi, Fukamachi Isamu, Tokutake Takayoshi, Ebinuma Hiroyuki, Takubo Kohei, Kaneko Hiroyuki, Kasuga Kensaku, Kakita Akiyoshi, Takahashi Hitoshi, Bujo Hideaki, Saito Yasushi, Nishizawa Masatoyo
Abstract excerpt
BACKGROUND: Recent genetic and pathological studies have suggested that a lipoprotein receptor, LR11, is intricately implicated in the pathogenesis of Alzheimer disease (AD). We have recently established a novel sandwich ELISA, which enabled the sensitive quantification of a soluble LR11 (sLR11). By this ELISA, we attempted to determine the difference in the levels of CSF sLR11 in AD patients. METHODS: We...
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