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Article

Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Nov 2008

Dodson Sara E, Andersen Olav M, Karmali Vinit, Fritz Jason J, Cheng Dongmei, Peng Junmin, Levey Allan I, Willnow Thomas E, Lah James J

Abstract excerpt

Alzheimer's disease (AD) is the most prevalent form of dementia, resulting in progressive neuronal death and debilitating damage to brain loci that mediate memory and higher cognitive function. While pathogenic genetic mutations have been implicated in approximately 2% of AD cases, the proximal events that underlie the common, sporadic form of the disease are incompletely understood. Converging lines of evidence...

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Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Dosage

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Source

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Identifiers

PMID: 19036982
DOI: 10.1523/JNEUROSCI.4582-08.2008
PMCID: PMC2669320

Genes

APP
SORL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease.PMID 19036982Read ↗

LR11/SorLA Expression Is Reduced in Sporadic Alzheimer Disease but not in Familial Alzheimer DiseaseSemantic proximity Read ↗

Lysosomal Sorting of Amyloid-β by the SORLA Receptor Is Impaired by a Familial Alzheimer’s Disease MutationSemantic proximity Read ↗

Potentially Pathogenic SORL1 Mutations Observed in Autosomal-Dominant Cases of Alzheimer's Disease Do Not Modulate APP Physiopathological Processing.Semantic proximity Read ↗

Potentially pathogenic SORL1 mutations observed in autosomal-dominant cases of Alzheimer’s disease do not modulate bAPP physiopathological processingSemantic proximity Read ↗

Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease.Semantic proximity Read ↗

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.Semantic proximity Read ↗

Modulation of amyloid β-protein clearance and Alzheimer’s disease susceptibility by the LDL receptor–related protein pathwaySemantic proximity Read ↗

SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid depositionSemantic proximity Read ↗

ApoE-isoform-dependent cellular uptake of amyloid-β is mediated by lipoprotein receptor LR11/SorLA.Semantic proximity Read ↗

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.Semantic proximity Read ↗

Brain-Derived Neurotrophic Factor Reduces Amyloidogenic Processing through Control of SORLA Gene ExpressionSemantic proximity Read ↗

Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related proteinSemantic proximity Read ↗

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